P0300 on Ford vehicles
92 owner complaints filed with NHTSA about Ford vehicles mention P0300 (Random/Multiple Cylinder Misfire Detected) - across 11 models. Below is where it shows up, by model and year.
Can you drive with it? Short trips at moderate speed are usually tolerable; a flashing check engine light means stop - raw fuel is destroying the catalytic converter.
Symptoms, likely causes in order and realistic repair costs are on the main P0300 page - they do not differ much by brand. This page shows what is specific to Ford: which models and years actually report it.
Ford models reporting P0300
The number next to each year is how many NHTSA complaints for that car mention P0300. Owners rarely quote trouble codes when complaining, so real occurrence is many times higher - use these numbers to compare years, not as totals.
What Ford owners report
“Engine started having a rough idle on start up and within a few days the check engine light came on. Took to Lonnie Cobb Ford in Henderson, TN. DTC P0300 and P0302 diagnosed. Coolant leaking on to piston head. Issue involved in lawsuit Miller vs. FordMotor Ecoboost lawsuit. Safety issue due to possible engine lock up or fire. Out of warranty. Quote for $6500 on an $8000 vehicle for an engine defect Ford has been aware of for years.”2016 Ford Edge · Jul 2026
“The vehicle in question has the coolant intrusion into cylinders 2 and 3 with rough idle on startup, P0300, P0302, P0303, and white smoke on startup. The vehicle now has 111339 miles on it and the out of pocket cost is more than what the vehicle blue books for in excellent condition. TSB 22-2134 speaks to all the issue and what the repair is. If this is a known issue then I feel this should be a vehicle recall by Ford due to the costly repair.”2017 Ford Fusion · Jul 2026
“I experienced rough idle and smell of coolant at start up. Engine light came on. Took car to dealership for diagnosis. Dealer verified my concern ran pcm self test, p0300, p0302 p0303 p0316 present, found coolant intrusion into cylinders. Dealer replaced long block per wsm 303-01. Cost to me $8,036.29. My 2017 Edge had 72,177 miles.”2017 Ford Edge · Jul 2026
“I own a 2020 Ford Mustang EcoBoost with approximately 75,000 miles. My vehicle developed a check engine light with diagnostic codes P0300 (random misfire) and P0301 (cylinder 1 misfire). I also began experiencing white smoke from the exhaust during cold starts. An independent repair shop suspects coolant is entering cylinder 1 due to a possible head gasket failure. They have recommended removing the cylinder head to inspect for cracks, check for warping, pressure test the head, inspect the cylinder walls, and replace the head gasket and related components if no further engine damage is found. The vehicle was properly maintained, and these symptoms appeared unexpectedly.”2020 Ford Mustang · Jul 2026
P0300 on other makes
Makes with enough NHTSA reports of P0300 for their own page.
Counts are NHTSA owner complaints whose text mentions P0300 - owner-reported and unverified. Always confirm with a diagnosis of your specific vehicle.