P0300 on Honda vehicles
45 owner complaints filed with NHTSA about Honda vehicles mention P0300 (Random/Multiple Cylinder Misfire Detected) - across 8 models. Below is where it shows up, by model and year.
Can you drive with it? Short trips at moderate speed are usually tolerable; a flashing check engine light means stop - raw fuel is destroying the catalytic converter.
Symptoms, likely causes in order and realistic repair costs are on the main P0300 page - they do not differ much by brand. This page shows what is specific to Honda: which models and years actually report it.
Honda models reporting P0300
The number next to each year is how many NHTSA complaints for that car mention P0300. Owners rarely quote trouble codes when complaining, so real occurrence is many times higher - use these numbers to compare years, not as totals.
What Honda owners report
“vehicle may experience driveability issues, which may result in DTCs P0300 (random misfire detected), P0301 (No. 1 cylinder misfire detected), P0302 (No. 2 cylinder misfire detected), P0303 (No. 3 cylinder misfire detected), P0304 (No. 4 cylinder misfire detected), or P0172 (fuel system too rich) or a whirling noise coming from the engine compartment. POSSIBLE CAUSE Based on certain driving patterns and environmental factors, the DTC's stated above may be set or a whirling noise may occur. Apparently only certain vin numbers were affected, mine is not in the list but im still having the exact same issues.”2017 Honda CR-V · Aug 2026
P0300 on other makes
Makes with enough NHTSA reports of P0300 for their own page.
Counts are NHTSA owner complaints whose text mentions P0300 - owner-reported and unverified. Always confirm with a diagnosis of your specific vehicle.