P0301 on Honda vehicles
86 owner complaints filed with NHTSA about Honda vehicles mention P0301 (Cylinder 1 Misfire Detected) - across 8 models. Below is where it shows up, by model and year.
Can you drive with it? Minimize driving; a flashing check engine light means stop - persistent single-cylinder misfire dumps raw fuel into the exhaust.
Symptoms, likely causes in order and realistic repair costs are on the main P0301 page - they do not differ much by brand. This page shows what is specific to Honda: which models and years actually report it.
Honda models reporting P0301
The number next to each year is how many NHTSA complaints for that car mention P0301. Owners rarely quote trouble codes when complaining, so real occurrence is many times higher - use these numbers to compare years, not as totals.
What Honda owners report
“just got on the freeway when car lost power, slowed down, check engine light turns on, and more lights start flashing. Potentially could have caused an accident if I was going faster on road. Went to mechanic, Code P0301, after diagnosis, fuel injectors failing. Mechanic was able to reproduce incident. Similar to recall for previous models, but not recalled on 2022 model. Need to replace fuel injectors. Had minor loss of power a few days prior, but not as severe”2022 Honda Ridgeline · Sep 2026
“vehicle may experience driveability issues, which may result in DTCs P0300 (random misfire detected), P0301 (No. 1 cylinder misfire detected), P0302 (No. 2 cylinder misfire detected), P0303 (No. 3 cylinder misfire detected), P0304 (No. 4 cylinder misfire detected), or P0172 (fuel system too rich) or a whirling noise coming from the engine compartment. POSSIBLE CAUSE Based on certain driving patterns and environmental factors, the DTC's stated above may be set or a whirling noise may occur. Apparently only certain vin numbers were affected, mine is not in the list but im still having the exact same issues.”2017 Honda CR-V · Aug 2026
P0301 on other makes
Makes with enough NHTSA reports of P0301 for their own page.
Counts are NHTSA owner complaints whose text mentions P0301 - owner-reported and unverified. Always confirm with a diagnosis of your specific vehicle.